The metabolism of N,N-dimethyl-p-aminoazobenzene and related compounds.
نویسندگان
چکیده
Studies on the metabolism of azo compounds related to p-aminoazobenzene in the rat so far have indicated that: (a) Fission of the azo linkage occurs (4, 12); (b) Dealkylation of N-methyl derivatives (10) and the N-ethyl derivative (5) occurs, at least to some extent, prior to reduction fission; (c) Partial reduction to hydrazo compounds which undergo a benzidine rearrangement in acid solution may also occur (2, 3). The results obtained in this laboratory bearing on this problem are reported below.
منابع مشابه
The carcinogenicity of certain compounds related to p-dimethylaminoazobenzene.
Many aminoazobenzene derivatives have been tested for carcinogenic activity in the rat (1-7). N,N-dimethyl-p-aminoazobenzene and N-methyl-paminoazobenzene have been found to be equally carcinogenic (4, 7). They produced cholangiomas and hepatomas in all animals tested in approximately the same period of time. N,N-dimethyl-3'methyl-4-aminoazobenzene was more carcinogenic than the parent compound...
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It has been known since 1932 (23) that 4'-amino2,3'-azotoluene will induce liver tumors in rats receiving the dye orally. Later, Kinosita (10) demonstrated the superior carcinogenic activity of an isomeric azo dye, N,N-dimethyl-p-arninoazobenzene, toward the rat liver; this superiority was revealed both in the shorter minimal feeding period and in the shorter latent period. Both these azo dyes ...
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N-Benzoyloxy-N-methyl-4-aminoazobenzene, a synthetic model ultimate carcinogenic derivative of N-methyl- and N,N-dimethyl-4-aminoazobenzene, reacted with [8-14C]deoxyguanosine in vitro to yield ten 14C-containing products separable by high-performance liquid chromatography. N-(Deoxyguanosin-8-yl)-N-methyl-4-aminoazobenzene, previously characterized as the major adduct formed in this reaction, o...
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عنوان ژورنال:
- Cancer research
دوره 7 2 شماره
صفحات -
تاریخ انتشار 1947